{"product_id":"153775863_product","title":"Karl S. Matlin - Crossing the Boundaries of Life : Gunter Blobel and t","description":"New Store Stock\u003cbr\u003e\u003cstrong\u003eAbout this Item\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eThe item is a book Hardback\u003cbr\u003eThe Author Name is Karl S. Matlin\u003cbr\u003eThe Title is Crossing the Boundaries of Life : Gunter Blobel and the Origins of Molecular Cell Biology\u003cbr\u003e\u003cbr\u003eCondition New\u003cbr\u003e\u003cbr\u003eOther Comments\u003cbr\u003eNew Store Stock\u003cbr\u003eCategory - Science\u003cbr\u003e\u003cbr\u003e\u003cbr\u003eProduct Description -\u003cbr\u003eA close look at Gunter Blobel's transformative contributions to molecular cell biology.    The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S.\r\n\r\n Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Gunter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details.\r\n\r\n For elaborating his signal concept into a process he termed membrane topogenesis-the idea that each protein in the cell is synthesized with an \"address\" that directs the protein to its correct destination within the cell-Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999.    Matlin argues that Blobel's investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning-the relationship between structure and function-allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.\u003cbr\u003e\u003cp\u003eWhen possible we will add details of the items we are selling to help buyers know what is included in the item for sale. The details are provided automatically from our central master database and can sometimes be wrong.\u003c\/p\u003e\n\n\u003cp\u003eBooks are released in many editions and variations, such as standard edition, re-issue, not for sale, promotional, special edition, limited edition, and many other editions and versions.  The Book you receive could be any of these editions or variations. If you are looking for a specific edition or version please contact us to verify what we are selling.\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eGift Ideas\u003c\/strong\u003e\u003cbr\u003e\nThis is a great gift idea.\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHours of Service\u003c\/strong\u003e\u003cbr\u003e\nWe have many warehouses, some of the warehouses process orders seven days a week, but the Administration Support Staff are located at a head office location, outside of the warehouses, and typically work only Monday to Friday.\u003c\/p\u003e\n\u003cbr\u003eLocation ID 245z\u003cbr\u003e\u003cbr\u003eiHaveit SKU ID 174118729\u003cbr\u003e\u003cbr\u003e","brand":"Convening Science: Discovery at the Marine Biological Laboratory","offers":[{"title":"Default Title \/ unisex","offer_id":45548656656628,"sku":"174118729","price":79.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/ihaveitmarketplace.com\/products\/153775863_product","provider":"iHaveit","version":"1.0","type":"link"}